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Leopard Guides: Hardware & Drivers
Serial devices communicate with a computer through a serial port, which transmits and receives data in a serial bit stream. In Mac OS X, developers can access serial-port devices through the I/O Kit in conjunction with the POSIX termios API. The I/O Kit also supports the development of serial controller drivers.

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CCL Modem Scripting Guide (HTML) (PDF)
2007-06-28
HBA Device Driver Programming Guide (HTML) (PDF)
Describes how to develop a high-performance, kernel-resident driver for an HBA device.
2006-05-23
Device File Access Guide for Serial Devices (HTML) (PDF)
Guidelines for using I/O Kit and POSIX functions to develop applications that communicate with serial devices.
2005-12-06